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UCT RESEARCH REPORT 2012
Nyoni, D., Lobb, K.A., Kaye, P.T. and Caira, M.R. 2012.
DBU-mediated cleavage of aryl- and heteroaryl disulfides.
ARKIVOC, iv: 245-252.
Ongarora, D.S.B., Gut, J., Rosenthal, P.J., Masimirembwa,
C.M. and Chibale, K. 2012. Benzoheterocyclic amodiaquine
analogues with potent antiplasmodial activity: synthesis
and pharmacological evaluation. Bioorganic & Medicinal
Chemistry Letters, 22: 5046-5050.
Paquet, T., Gordon, R., Waterson, D., Witty, M.J. and
Chibale, K. 2012. Antimalarial aminothiazoles and
aminopyridines from phenotypic whole-cell screening of a
SoftFocus library. Future Medicinal Chemistry, 4(18): 2265-
2277.
Ramon, G., Nassimbeni, L.R. and Taljaard, J.H. 2012. Guest
controlled packing in inclusion compounds. Journal of
Chemical Crystallography, 42: 1014-1021.
Sharma, R.K., Douglas, R.G., Louw, S., Chibale, K. and
Sturrock, E.D. 2012.Newketomethylene inhibitor analogues:
synthesis and assessment of structural determinants for
N-domain selective inhibition of angiotensin-converting
enzyme. Biological Chemistry, 393: 485-493.
Singh, K., Kaur, H., Chibale, K., Balzarini, J., Little, S.
and Bharatam, P.V. 2012. 2-Aminopyrimidine based
4-aminoquinoline anti-plasmodial agents. Synthesis,
biological activity, structure-activity relationship and mode
of action studies. European Journal of Medicinal Chemistry,
52: 82-97.
Stringer, T., Hendricks, D.T., Guzgay, H. and Smith, G.S. 2012.
Synthesis and characterization of multimeric salicylaldimine
thiosemicarbazones and their Pd(II) and Pt(II) complexes.
Polyhedron, 31: 486-493.
Tacon, C., Guantai, E.M., Smith, P.J. and Chibale, K. 2012.
Synthesis, biological evaluation and mechanistic studies of
totarol amino alcohol derivatives as potential antimalarial
agents. Bioorganic & Medicinal Chemistry, 20: 893-902.
Theka, T., Rodgers, A., Lewandowski, S., Webber, D. and
Allie-Hamdulay, S. 2012. Effects of vitamin E ingestion
on plasma and urinary risk factors for calcium oxalate
urolithiasis in two population groups having different
stone-risk profiles: evidence of different physiological
handling mechanisms. Urological Research, 40: 113-120.
Thelingwani, R.S., Dhansay, K., Smith, P., Chibale, K. and
Masimirembwa, C.M. 2012. Potent inhibition of CYP1A2
by frutinone A, an active ingredient of the broad spectrum
antimicrobial herbal extract from P.fruticosa. Xenobiotica,
42(10): 989-1000.
Tukulula, M., Little, S., Gut, J., Rosenthal, P.J., Wan,
B., Franzblau, S.G. and Chibale, K. 2012. The design,
synthesis, in silico ADME profiling, antiplasmodial and
antimycobacterial evaluation of new arylamino quinoline
derivatives. European Journal of Medicinal Chemistry, 57:
259-267.
Wang, X., Rotkina, L., Su, H. and Beckmann, P.A. 2012.
Single-crystal x-ray diffraction, isolated-molecule and cluster
electronic structure calculations, and scanning electron
microscopy in an organic solid: models for intramolecular
motion in 4,4’-dimethoxybiphenyl. Chemphyschem, 13:
2082-2089.
Younis, Y., Douelle, F., Feng, T.-S., Cabrera, D.G., LeManach,
C., Nchinda, A.T., Duffy, S., White, K.L., Shackleford,
D.M., Morizzi, J., Mannila, J., Katneni, K., Bhamidipati, R.,
Zabiulla, K.M., Joseph, J.T., Bashyam, S., Waterson, D.,
Witty, M.J., Hardick, D., Wittlin, S., Avery, V., Charman,
S.A. and Chibale, K. 2012. 3,5-Diaryl-2-aminopyridines as
a novel class of orally active antimalarials demonstrating
single dose cure in mice and clinical candidate potential.
Journal of Medicinal Chemistry, 55: 3479-3487.
Doctoral dissertations
Davies, K. 2012. Metal-organic frameworks and their uses
as gas sorption devices. 214pp. Supervised by Bourne, S.A.
Dhansay, K. 2012. Isolation and identificationof antimicrobial
compounds from South African medicinal plants. 166pp.
Supervised by Smith, P.J. and Chibale, K.
Gamieldien, M.R. 2012. Parameterization of the Gay-
Berne coarse-grain potential from atomistically detailed
anisotropic free energy volumes. 178pp. Supervised by
Naidoo, K.J.
Jayakody, R.S. 2012. In silico investigation of the mechanism
of ricin-catalysed depurination reaction and design of
novel ricin inhibitors. 210pp. Supervised by Naidoo, K.J.
Kambafwile, H.K. 2012. Synthesis of activity-based protein
profiling probes for malaria and hypertension disease
models and potential novel ACE inhibitors with an
attenuated zinc binding group. 223pp. Supervised by
Chibale, K. and Sturrock, E.
Makhubela, B.C.E. 2012. The design, synthesis and
characterisation of polynuclear materials for applications in
catalysis. 135pp. Supervised by Smith, G.S. and Jardine, A.
Malatji, P. 2012. Studies towards degradable polymers:
new zinc(II) and palladium(II) complexes as catalysts for
lactide polymerization and carbon monoxide/styrene